BDBM50111455 (1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-5-(2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid isopropyl ester::4-(3-(3,4-Difluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-5-(2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid isopropyl ester::CHEMBL291276

SMILES: CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O

InChI Key: InChIKey=IDEQIHVMYCERBI-QNSPMPMTSA-N

Data: 15 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50111455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 13)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	132	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 1A)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 23)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 3)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	109	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 9)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 16)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 14)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 78)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 2)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 11)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 19)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype Hanks)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 25)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 39)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50111455 ((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...) Show SMILES CC(C)OC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](Cc1ccc(F)c(F)c1)n1cccc(NC(=O)c2cc(C)on2)c1=O Show InChI InChI=1S/C31H33F2N5O7/c1-17(2)44-27(39)9-7-21(16-20-10-11-34-28(20)40)35-30(42)26(15-19-6-8-22(32)23(33)14-19)38-12-4-5-24(31(38)43)36-29(41)25-13-18(3)45-37-25/h4-9,12-14,17,20-21,26H,10-11,15-16H2,1-3H3,(H,34,40)(H,35,42)(H,36,41)/b9-7+/t20-,21+,26-/m0/s1	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	85	n/a	n/a	n/a	n/a
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals Curated by ChEMBL					Assay Description antirhinoviral activity against HRV Protease 3CP (serotype 10)				J Med Chem 45: 1607-23 (2002) BindingDB Entry DOI: 10.7270/Q27M078G
					More data for this Ligand-Target Pair