BDBM50115919 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methoxymethyl-benzyl ester::CHEMBL63106
SMILES: COCc1ccccc1COC(=O)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1
InChI Key: InChIKey=QGPSHWUWMGSFJB-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50115919 (4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description The concentration required to displace 50% of a highly potent radiolabeled FPTase inhibitor | Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50115919 (4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATP | Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50115919 (4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibitor of Farnesyl protein transferase(FTPase) required to reduce radiolabel [1-3H] incorporation by 50% | Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS | |||||||||||
More data for this Ligand-Target Pair |