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BDBM50117937 (+)4-(2-{4-[9-bromo-4-chloro-1-methyl-(12R)-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl]hexahydro-1-pyridinyl}-2-oxoethyl)-1-pyridiniumolate::CHEMBL127697

SMILES: Cc1c[nH]c2c(Cl)cc3CCc4cc(Br)cnc4[C@H](C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12

InChI Key: InChIKey=USAPKSGHDXEZDU-HHHXNRCGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50117937   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))		BDBM50117937
PNG
((+)4-(2-{4-[9-bromo-4-chloro-1-methyl-(12R)-3,6,7,...)
Show SMILES Cc1c[nH]c2c(Cl)cc3CCc4cc(Br)cnc4[C@H](C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12
Show InChI InChI=1S/C29H28BrClN4O2/c1-17-15-32-29-23(31)14-20-2-3-21-13-22(30)16-33-28(21)27(26(20)25(17)29)19-6-8-34(9-7-19)24(36)12-18-4-10-35(37)11-5-18/h4-5,10-11,13-16,19,27,32H,2-3,6-9,12H2,1H3/t27-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.60n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val

J Med Chem 45: 3854-64 (2002)


BindingDB Entry DOI: 10.7270/Q2TD9WPB
More data for this
Ligand-Target Pair