BDBM50121036 CHEMBL421054::[(S)-1-((R)-7-Oxo-4-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-2-(S)-phenyl-ethyl]-carbamic acid benzyl ester
SMILES: O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1[C@@H]2SCCN2C1=O)OCc1ccccc1
InChI Key: InChIKey=MKBBOQYCGLQYLG-UEXGIBASSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin L (Rattus norvegicus) | BDBM50121036 (CHEMBL421054 | [(S)-1-((R)-7-Oxo-4-thia-1-aza-bicy...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Homo sapiens (Human)) | BDBM50121036 (CHEMBL421054 | [(S)-1-((R)-7-Oxo-4-thia-1-aza-bicy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin K (Homo sapiens (Human)) | BDBM50121036 (CHEMBL421054 | [(S)-1-((R)-7-Oxo-4-thia-1-aza-bicy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair |