BDBM50124708 CHEMBL3622927

SMILES: COc1cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc(OC)c1OC

InChI Key: InChIKey=YHWMDQWUDYPHHE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50124708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124708 (CHEMBL3622927) Show SMILES COc1cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc(OC)c1OC Show InChI InChI=1S/C22H27N5O4/c1-14-9-27(11-15(14)10-26-12-17(28)13-26)20-5-6-23-22(25-20)24-16-7-18(29-2)21(31-4)19(8-16)30-3/h5-9,11,17,28H,10,12-13H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair