BDBM50125658 (S)-2-[2-(3-Fluoro-phenyl)-acetylamino]-4-methyl-pentanoic acid ((1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-oxo-4-phenyl-butyl)-amide::CHEMBL280199
SMILES: CC(C)C[C@H](NC(=O)Cc1cccc(F)c1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1
InChI Key: InChIKey=SMULLMIPSOYMDE-FEVNIDIWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human)) | BDBM50125658 ((S)-2-[2-(3-Fluoro-phenyl)-acetylamino]-4-methyl-p...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. | Bioorg Med Chem Lett 13: 1203-6 (2003) BindingDB Entry DOI: 10.7270/Q279442Z | |||||||||||
More data for this Ligand-Target Pair |