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SMILES: Cc1cc(ccn1)-c1ccc(OC(=O)Nc2ccc(cn2)-c2cnccn2)cc1

InChI Key: InChIKey=AQUPHPLXUVSULY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50125941   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens (Human))		BDBM50125941
PNG
(CHEMBL3623875)
Show SMILES Cc1cc(ccn1)-c1ccc(OC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C22H17N5O2/c1-15-12-17(8-9-24-15)16-2-5-19(6-3-16)29-22(28)27-21-7-4-18(13-26-21)20-14-23-10-11-25-20/h2-14H,1H3,(H,26,27,28)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 0.230n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...

Bioorg Med Chem 23: 6855-68 (2015)


BindingDB Entry DOI: 10.7270/Q2J10500
More data for this
Ligand-Target Pair