BDBM50127317 2-(4-Acetyl-piperazin-1-yl)-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL39805

SMILES: CC(=O)N1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1

InChI Key: InChIKey=NSUUDAUUQPVPAO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50127317   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50127317 (2-(4-Acetyl-piperazin-1-yl)-5-(3-chloro-phenyl)-6-...) Show SMILES CC(=O)N1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 Show InChI InChI=1S/C31H28ClN7O2/c1-21(40)38-10-12-39(13-11-38)31-25(17-34)15-27(24-4-3-5-26(32)14-24)28(36-31)19-41-30(29-18-35-20-37(29)2)23-8-6-22(16-33)7-9-23/h3-9,14-15,18,20,30H,10-13,19H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50127317 (2-(4-Acetyl-piperazin-1-yl)-5-(3-chloro-phenyl)-6-...) Show SMILES CC(=O)N1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 Show InChI InChI=1S/C31H28ClN7O2/c1-21(40)38-10-12-39(13-11-38)31-25(17-34)15-27(24-4-3-5-26(32)14-24)28(36-31)19-41-30(29-18-35-20-37(29)2)23-8-6-22(16-33)7-9-23/h3-9,14-15,18,20,30H,10-13,19H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair