BDBM50129173 7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene::CHEMBL63788

SMILES: CC1CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12

InChI Key: InChIKey=QWPDENUMNMUTHR-UHFFFAOYSA-N

Data: 1 KI  2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50129173   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50129173 (7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...) Show SMILES CC1CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12 Show InChI InChI=1S/C19H19F2NO/c1-10-8-19(2,3)22-16-5-4-12-13-6-11(20)7-15(21)18(13)23-9-14(12)17(10)16/h4-7,10,22H,8-9H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human progesterone receptor activation in T47D human breast cancer cell.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50129173 (7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...) Show SMILES CC1CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12 Show InChI InChI=1S/C19H19F2NO/c1-10-8-19(2,3)22-16-5-4-12-13-6-11(20)7-15(21)18(13)23-9-14(12)17(10)16/h4-7,10,22H,8-9H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Antagonistic activity at human progesterone receptor in CV-1 cells.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50129173 (7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...) Show SMILES CC1CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12 Show InChI InChI=1S/C19H19F2NO/c1-10-8-19(2,3)22-16-5-4-12-13-6-11(20)7-15(21)18(13)23-9-14(12)17(10)16/h4-7,10,22H,8-9H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	217	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human progesterone receptor activation in T47D human breast cancer cell.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50129173 (7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...) Show SMILES CC1CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12 Show InChI InChI=1S/C19H19F2NO/c1-10-8-19(2,3)22-16-5-4-12-13-6-11(20)7-15(21)18(13)23-9-14(12)17(10)16/h4-7,10,22H,8-9H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of antagonist activity towards human androgen receptor				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair