BDBM50130765 CHEMBL3634860

SMILES: COc1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(n1)-c1ccc(F)cc1

InChI Key: InChIKey=GTDHTOCGWNZONB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50130765   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50130765 (CHEMBL3634860) Show SMILES COc1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21FN2O2/c1-32-27-17-16-25(28(31-27)21-6-11-22(29)12-7-21)19-9-14-24(15-10-19)33-18-23-13-8-20-4-2-3-5-26(20)30-23/h2-17H,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Centre Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...				J Med Chem 58: 8292-308 (2015) BindingDB Entry DOI: 10.7270/Q2833TVD
					More data for this Ligand-Target Pair