BDBM50134443 CHEMBL3746457
SMILES: Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
InChI Key: InChIKey=CNYVJDHTGDPUBS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 6.76E+3 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRM7 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50134443 (CHEMBL3746457) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Inhibition of human ERG | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells assessed as calcium mobilization by fluorescence analysis | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by [35S]-GTPgammaS binding assay | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells by [35S]-GTPgammaS binding assay | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (mGlu6) (Rattus norvegicus (Rat)) | BDBM50134443 (CHEMBL3746457) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assay | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRM8 (Homo sapiens (Human)) | BDBM50134443 (CHEMBL3746457) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis | Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS | |||||||||||
More data for this Ligand-Target Pair |