BDBM50134476 CHEMBL3746299

SMILES: Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)c(Cl)c2C1=O

InChI Key: InChIKey=IJVRAFCZLKHDLC-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134476   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50134476 (CHEMBL3746299) Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)c(Cl)c2C1=O Show InChI InChI=1S/C19H15ClFN3O2/c20-17-16(12-26-15-4-2-1-3-5-15)22-24-11-10-23(19(25)18(17)24)14-8-6-13(21)7-9-14/h1-9H,10-12H2	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50134476 (CHEMBL3746299) Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)c(Cl)c2C1=O Show InChI InChI=1S/C19H15ClFN3O2/c20-17-16(12-26-15-4-2-1-3-5-15)22-24-11-10-23(19(25)18(17)24)14-8-6-13(21)7-9-14/h1-9H,10-12H2	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	<3.02E+4	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS
					More data for this Ligand-Target Pair