BDBM50134480 CHEMBL3746731

SMILES: Fc1cccc(c1)N1CCn2nc(COc3ccccc3)cc2C1=O

InChI Key: InChIKey=FBVKGXIAMJWSEZ-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50134480 (CHEMBL3746731) Show SMILES Fc1cccc(c1)N1CCn2nc(COc3ccccc3)cc2C1=O Show InChI InChI=1S/C19H16FN3O2/c20-14-5-4-6-16(11-14)22-9-10-23-18(19(22)24)12-15(21-23)13-25-17-7-2-1-3-8-17/h1-8,11-12H,9-10,13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	126	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50134480 (CHEMBL3746731) Show SMILES Fc1cccc(c1)N1CCn2nc(COc3ccccc3)cc2C1=O Show InChI InChI=1S/C19H16FN3O2/c20-14-5-4-6-16(11-14)22-9-10-23-18(19(22)24)12-15(21-23)13-25-17-7-2-1-3-8-17/h1-8,11-12H,9-10,13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 429-34 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1NGS
					More data for this Ligand-Target Pair