BDBM50134648 (6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperidin-1-yl)-methanone::(6-hydroxy-1H-indole-2-yl)-(4-phenoxymethylpiperidine-1-yl)-methanone::CHEMBL127510

SMILES: Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1

InChI Key: InChIKey=YFLRVMPCONWBFK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50134648   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134648 ((6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperid...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-15(9-11-23)14-26-18-4-2-1-3-5-18/h1-7,12-13,15,22,24H,8-11,14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
GluN1/GluN2B NMDA receptor (Homo sapiens (Human))	BDBM50134648 ((6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperid...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-15(9-11-23)14-26-18-4-2-1-3-5-18/h1-7,12-13,15,22,24H,8-11,14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B				Bioorg Med Chem Lett 13: 3859-61 (2003) BindingDB Entry DOI: 10.7270/Q2TH8M32
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134648 ((6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperid...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-15(9-11-23)14-26-18-4-2-1-3-5-18/h1-7,12-13,15,22,24H,8-11,14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair