BDBM50135326 1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-6-(4-fluoro-phenylsulfanyl)-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one::CHEMBL128515

SMILES: Fc1ccc(Sc2ccc3N(C(=O)NCc3n2)c2c(Cl)cc(cc2Cl)C(F)(F)F)cc1

InChI Key: InChIKey=VUISSSBBPOJRTO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135326   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50135326 (1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-6-(4-flu...) Show SMILES Fc1ccc(Sc2ccc3N(C(=O)NCc3n2)c2c(Cl)cc(cc2Cl)C(F)(F)F)cc1 Show InChI InChI=1S/C20H11Cl2F4N3OS/c21-13-7-10(20(24,25)26)8-14(22)18(13)29-16-5-6-17(28-15(16)9-27-19(29)30)31-12-3-1-11(23)2-4-12/h1-8H,9H2,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha				Bioorg Med Chem Lett 13: 3979-82 (2003) BindingDB Entry DOI: 10.7270/Q2RJ4HWB
					More data for this Ligand-Target Pair