BDBM50135640 3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-dimethylamino-propyl)-amide::CHEMBL317554
SMILES: CN(C)CCCN(C(=O)c1sc2ccccc2c1Cl)c1ccccc1SCc1ccccc1
InChI Key: InChIKey=ZUAPVLUALHYVIF-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuropeptide Y receptor type 2 (Homo sapiens (Human)) | BDBM50135640 (3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]-PYY from NPYY2 receptor (unknown origin) | Bioorg Med Chem Lett 24: 430-41 (2014) Article DOI: 10.1016/j.bmcl.2013.11.061 BindingDB Entry DOI: 10.7270/Q2H133HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 2 (Homo sapiens (Human)) | BDBM50135640 (3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity against SMS-KAN cell membranes endogenously expressing Neuropeptide Y receptor type 2 using [125I]-PYY as radioligand | Bioorg Med Chem Lett 13: 2883-5 (2003) BindingDB Entry DOI: 10.7270/Q2F47NJQ | |||||||||||
More data for this Ligand-Target Pair |