BDBM50136357 CHEMBL341982::N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-3-dimethylamino-propionamide
SMILES: CN(C)CCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(CC1)C1CCCCC1
InChI Key: InChIKey=PULMVELKNAGMQU-RUZDIDTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50136357 (CHEMBL341982 | N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyc...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptors | Bioorg Med Chem Lett 13: 4341-4 (2003) BindingDB Entry DOI: 10.7270/Q2F18Z4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50136357 (CHEMBL341982 | N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyc...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptor | Bioorg Med Chem Lett 14: 4417-23 (2004) Article DOI: 10.1016/j.bmcl.2004.06.059 BindingDB Entry DOI: 10.7270/Q2251HPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50136357 (CHEMBL341982 | N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyc...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Stimulation of adenylate cyclase in HEK293 cells expressing the human MC4R receptor was determined by measuring cAMP accumulation using the RPA559 SP... | Bioorg Med Chem Lett 13: 4341-4 (2003) BindingDB Entry DOI: 10.7270/Q2F18Z4D | |||||||||||
More data for this Ligand-Target Pair |