BDBM50136358 CHEMBL137318::N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-3-(2,2,2-trifluoro-acetylamino)-propionamide

SMILES: FC(F)(F)C(=O)NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(CC1)C1CCCCC1

InChI Key: InChIKey=VJBLXWDMNUFOKM-HSZRJFAPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50136358   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50136358 (CHEMBL137318 | N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyc...) Show SMILES FC(F)(F)C(=O)NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(CC1)C1CCCCC1 Show InChI InChI=1S/C28H36ClF3N6O3/c29-22-8-6-20(7-9-22)16-23(36-24(39)10-13-34-26(41)28(30,31)32)25(40)37-14-11-27(12-15-37,17-38-19-33-18-35-38)21-4-2-1-3-5-21/h6-9,18-19,21,23H,1-5,10-17H2,(H,34,41)(H,36,39)/t23-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptors				Bioorg Med Chem Lett 13: 4341-4 (2003) BindingDB Entry DOI: 10.7270/Q2F18Z4D
					More data for this Ligand-Target Pair