US11026923, Example 8 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine

SMILES: CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c(NC(C)C)c(n1)C(C)=N

InChI Key: InChIKey=HRQDHIDSKXKALG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501373   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM501373 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(2...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c(NC(C)C)c(n1)C(C)=N Show InChI InChI=1S/C20H27N9O/c1-6-30-20-14(8-7-9-22-20)15-10-16(23-11-17-26-28-29(5)27-17)19(24-12(2)3)18(25-15)13(4)21/h7-10,12,21,24H,6,11H2,1-5H3,(H,23,25)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM501373 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(2...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c(NC(C)C)c(n1)C(C)=N Show InChI InChI=1S/C20H27N9O/c1-6-30-20-14(8-7-9-22-20)15-10-16(23-11-17-26-28-29(5)27-17)19(24-12(2)3)18(25-15)13(4)21/h7-10,12,21,24H,6,11H2,1-5H3,(H,23,25)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM501373 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(2...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c(NC(C)C)c(n1)C(C)=N Show InChI InChI=1S/C20H27N9O/c1-6-30-20-14(8-7-9-22-20)15-10-16(23-11-17-26-28-29(5)27-17)19(24-12(2)3)18(25-15)13(4)21/h7-10,12,21,24H,6,11H2,1-5H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair