BDBM50137847 6-(5-Hydroxy-1,3-dioxo-6-piperidin-1-ylmethyl-1,3-dihydro-isoindol-2-yl)-hexanoic acid (2-amino-phenyl)-amide::CHEMBL318431

SMILES: Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cc(O)c(CN3CCCCC3)cc2C1=O

InChI Key: InChIKey=OSWSSQHHRGDJRU-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50137847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50137847 (6-(5-Hydroxy-1,3-dioxo-6-piperidin-1-ylmethyl-1,3-...) Show SMILES Nc1ccccc1NC(=O)CCCCCN1C(=O)c2cc(O)c(CN3CCCCC3)cc2C1=O Show InChI InChI=1S/C26H32N4O4/c27-21-9-4-5-10-22(21)28-24(32)11-3-1-8-14-30-25(33)19-15-18(17-29-12-6-2-7-13-29)23(31)16-20(19)26(30)34/h4-5,9-10,15-16,31H,1-3,6-8,11-14,17,27H2,(H,28,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Ability to inhibit recombinant human histone deacetylase 1 (HDAC-1).				Bioorg Med Chem Lett 14: 283-7 (2003) BindingDB Entry DOI: 10.7270/Q2BV7G17
					More data for this Ligand-Target Pair