BDBM50138759 5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,2,4]triazole-1-carboxylic acid dimethylamide::CHEMBL130478::N,N-dimethyl-5-(methylthio)-3-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole-1-carboxamide
SMILES: CSc1nc(nn1C(=O)N(C)C)-c1ccc(OC(F)(F)F)cc1
InChI Key: InChIKey=FBOHEFQKBNWFPO-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Hormone-sensitive lipase (HSL) (Homo sapiens (Human)) | BDBM50138759 (5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S Curated by ChEMBL | Assay Description Inhibition of hormone sensitive lipase (HSL). | J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholinesterases (Homo sapiens (Human)) | BDBM50138759 (5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S Curated by ChEMBL | Assay Description Inhibitory concentration against butyrylcholinesterase. | J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hormone-sensitive lipase (HSL) (Rattus norvegicus (Rat)) | BDBM50138759 (5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.76 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Jordan Curated by ChEMBL | Assay Description Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | J Med Chem 51: 6478-94 (2008) Article DOI: 10.1021/jm800718k BindingDB Entry DOI: 10.7270/Q23778KJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hormone sensitive lipase (Homo sapiens (Human)) | BDBM50138759 (5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of HSL (unknown origin) | J Med Chem 58: 6448-55 (2015) BindingDB Entry DOI: 10.7270/Q2N018BP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM50138759 (5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human AChE | J Med Chem 58: 6448-55 (2015) BindingDB Entry DOI: 10.7270/Q2N018BP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM50138759 (5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S Curated by ChEMBL | Assay Description Inhibitory concentration against acetylcholinesterase | J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1 | |||||||||||
More data for this Ligand-Target Pair |