BDBM50139378 4-{2-[2-(3-Hydroxy-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-benzonitrile::CHEMBL161624

SMILES: OC1CCN(CCc2cc3cc(ccc3o2)-c2ccc(cc2)C#N)C1

InChI Key: InChIKey=GXIARDOKAMVMMN-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50139378   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50139378 (4-{2-[2-(3-Hydroxy-pyrrolidin-1-yl)-ethyl]-benzofu...) Show SMILES OC1CCN(CCc2cc3cc(ccc3o2)-c2ccc(cc2)C#N)C1 Show InChI InChI=1S/C21H20N2O2/c22-13-15-1-3-16(4-2-15)17-5-6-21-18(11-17)12-20(25-21)8-10-23-9-7-19(24)14-23/h1-6,11-12,19,24H,7-10,14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50139378 (4-{2-[2-(3-Hydroxy-pyrrolidin-1-yl)-ethyl]-benzofu...) Show SMILES OC1CCN(CCc2cc3cc(ccc3o2)-c2ccc(cc2)C#N)C1 Show InChI InChI=1S/C21H20N2O2/c22-13-15-1-3-16(4-2-15)17-5-6-21-18(11-17)12-20(25-21)8-10-23-9-7-19(24)14-23/h1-6,11-12,19,24H,7-10,14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139378 (4-{2-[2-(3-Hydroxy-pyrrolidin-1-yl)-ethyl]-benzofu...) Show SMILES OC1CCN(CCc2cc3cc(ccc3o2)-c2ccc(cc2)C#N)C1 Show InChI InChI=1S/C21H20N2O2/c22-13-15-1-3-16(4-2-15)17-5-6-21-18(11-17)12-20(25-21)8-10-23-9-7-19(24)14-23/h1-6,11-12,19,24H,7-10,14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139378 (4-{2-[2-(3-Hydroxy-pyrrolidin-1-yl)-ethyl]-benzofu...) Show SMILES OC1CCN(CCc2cc3cc(ccc3o2)-c2ccc(cc2)C#N)C1 Show InChI InChI=1S/C21H20N2O2/c22-13-15-1-3-16(4-2-15)17-5-6-21-18(11-17)12-20(25-21)8-10-23-9-7-19(24)14-23/h1-6,11-12,19,24H,7-10,14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair