BDBM50139396 4-{2-[2-(3,6-Dihydro-2H-pyridin-1-yl)-ethyl]-benzofuran-5-yl}-benzonitrile::CHEMBL161133

SMILES: N#Cc1ccc(cc1)-c1ccc2oc(CCN3CCC=CC3)cc2c1

InChI Key: InChIKey=ZLCKROBKBCZLCK-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50139396   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50139396 (4-{2-[2-(3,6-Dihydro-2H-pyridin-1-yl)-ethyl]-benzo...) Show SMILES N#Cc1ccc(cc1)-c1ccc2oc(CCN3CCC=CC3)cc2c1 |c:20| Show InChI InChI=1S/C22H20N2O/c23-16-17-4-6-18(7-5-17)19-8-9-22-20(14-19)15-21(25-22)10-13-24-11-2-1-3-12-24/h1-2,4-9,14-15H,3,10-13H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50139396 (4-{2-[2-(3,6-Dihydro-2H-pyridin-1-yl)-ethyl]-benzo...) Show SMILES N#Cc1ccc(cc1)-c1ccc2oc(CCN3CCC=CC3)cc2c1 |c:20| Show InChI InChI=1S/C22H20N2O/c23-16-17-4-6-18(7-5-17)19-8-9-22-20(14-19)15-21(25-22)10-13-24-11-2-1-3-12-24/h1-2,4-9,14-15H,3,10-13H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139396 (4-{2-[2-(3,6-Dihydro-2H-pyridin-1-yl)-ethyl]-benzo...) Show SMILES N#Cc1ccc(cc1)-c1ccc2oc(CCN3CCC=CC3)cc2c1 |c:20| Show InChI InChI=1S/C22H20N2O/c23-16-17-4-6-18(7-5-17)19-8-9-22-20(14-19)15-21(25-22)10-13-24-11-2-1-3-12-24/h1-2,4-9,14-15H,3,10-13H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139396 (4-{2-[2-(3,6-Dihydro-2H-pyridin-1-yl)-ethyl]-benzo...) Show SMILES N#Cc1ccc(cc1)-c1ccc2oc(CCN3CCC=CC3)cc2c1 |c:20| Show InChI InChI=1S/C22H20N2O/c23-16-17-4-6-18(7-5-17)19-8-9-22-20(14-19)15-21(25-22)10-13-24-11-2-1-3-12-24/h1-2,4-9,14-15H,3,10-13H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair