BDBM50139458 CHEMBL3764994

SMILES: Clc1ccc(cc1)-c1csc(NCc2cncn2Cc2ccc(cc2)C#N)c1C#N

InChI Key: InChIKey=OJPCADPVISIEDM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50139458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139458 (CHEMBL3764994) Show SMILES Clc1ccc(cc1)-c1csc(NCc2cncn2Cc2ccc(cc2)C#N)c1C#N Show InChI InChI=1S/C23H16ClN5S/c24-19-7-5-18(6-8-19)22-14-30-23(21(22)10-26)28-12-20-11-27-15-29(20)13-17-3-1-16(9-25)2-4-17/h1-8,11,14-15,28H,12-13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UPR2301 Curated by ChEMBL					Assay Description Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay				Eur J Med Chem 109: 173-86 (2016) BindingDB Entry DOI: 10.7270/Q25B04C6
					More data for this Ligand-Target Pair