BDBM50139469 CHEMBL3763335

SMILES: [O-][N+](=O)c1ccc(Cn2cncc2CNc2scc(c2C#N)-c2ccc(Cl)cc2)cc1

InChI Key: InChIKey=BVDBXZCOEACWLX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50139469   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139469 (CHEMBL3763335) Show SMILES [O-][N+](=O)c1ccc(Cn2cncc2CNc2scc(c2C#N)-c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C22H16ClN5O2S/c23-17-5-3-16(4-6-17)21-13-31-22(20(21)9-24)26-11-19-10-25-14-27(19)12-15-1-7-18(8-2-15)28(29)30/h1-8,10,13-14,26H,11-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UPR2301 Curated by ChEMBL					Assay Description Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay				Eur J Med Chem 109: 173-86 (2016) BindingDB Entry DOI: 10.7270/Q25B04C6
					More data for this Ligand-Target Pair