BDBM50140600 (R)-5-((7-benzyl-5-ethyl-2-methoxy-4-oxo-4,5,7,8-tetrahydroimidazo[2,1-e]purin-3-yl)methyl)-2-hydroxybenzonitrile::5-[7-benzyl-5-ethyl-2-methoxy-4-oxo-(7R)-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-ylmethyl]-2-hydroxybenzonitrile::CHEMBL23513

SMILES: CCN1C2=N[C@H](Cc3ccccc3)CN2c2nc(OC)n(Cc3ccc(O)c(c3)C#N)c2C1=O

InChI Key: InChIKey=NMNLLKYIXYCGII-LJQANCHMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50140600 ((R)-5-((7-benzyl-5-ethyl-2-methoxy-4-oxo-4,5,7,8-t...) Show SMILES CCN1C2=N[C@H](Cc3ccccc3)CN2c2nc(OC)n(Cc3ccc(O)c(c3)C#N)c2C1=O |r,t:3| Show InChI InChI=1S/C25H24N6O3/c1-3-29-23(33)21-22(31-15-19(27-24(29)31)12-16-7-5-4-6-8-16)28-25(34-2)30(21)14-17-9-10-20(32)18(11-17)13-26/h4-11,19,32H,3,12,14-15H2,1-2H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Lavras-UFLA Curated by ChEMBL					Assay Description Inhibition of PDE5				Eur J Med Chem 43: 1632-8 (2008) Article DOI: 10.1016/j.ejmech.2007.10.019 BindingDB Entry DOI: 10.7270/Q2Q81F9P
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50140600 ((R)-5-((7-benzyl-5-ethyl-2-methoxy-4-oxo-4,5,7,8-t...) Show SMILES CCN1C2=N[C@H](Cc3ccccc3)CN2c2nc(OC)n(Cc3ccc(O)c(c3)C#N)c2C1=O |r,t:3| Show InChI InChI=1S/C25H24N6O3/c1-3-29-23(33)21-22(31-15-19(27-24(29)31)12-16-7-5-4-6-8-16)28-25(34-2)30(21)14-17-9-10-20(32)18(11-17)13-26/h4-11,19,32H,3,12,14-15H2,1-2H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzyme				Bioorg Med Chem Lett 14: 1291-4 (2004) Article DOI: 10.1016/j.bmcl.2003.12.027 BindingDB Entry DOI: 10.7270/Q2BG2NF0
					More data for this Ligand-Target Pair