BDBM50140723 5-(4-methoxyphenyl)-3-phenyl-(3R,3aS,6aR)-spiro[perhydrofuro[3,4-c]pyrrole-1,2'-(2',3'-dihydro-1'H-indene)]-1',3',4,6-tetraone::CHEMBL28432

SMILES: COc1ccc(cc1)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1

InChI Key: InChIKey=POARSKSBXGHKQY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50140723   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phenylalanyl-tRNA synthetase alpha chain (Streptococcus pyogenes serotype M18)	BDBM50140723 (5-(4-methoxyphenyl)-3-phenyl-(3R,3aS,6aR)-spiro[pe...) Show SMILES COc1ccc(cc1)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1 Show InChI InChI=1S/C27H19NO6/c1-33-17-13-11-16(12-14-17)28-25(31)20-21(26(28)32)27(34-22(20)15-7-3-2-4-8-15)23(29)18-9-5-6-10-19(18)24(27)30/h2-14,22,31-32H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus				Bioorg Med Chem Lett 14: 1339-42 (2004) Article DOI: 10.1016/j.bmcl.2003.11.081 BindingDB Entry DOI: 10.7270/Q2PR7VDS
					More data for this Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain (Streptococcus pyogenes serotype M18)	BDBM50140723 (5-(4-methoxyphenyl)-3-phenyl-(3R,3aS,6aR)-spiro[pe...) Show SMILES COc1ccc(cc1)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1 Show InChI InChI=1S/C27H19NO6/c1-33-17-13-11-16(12-14-17)28-25(31)20-21(26(28)32)27(34-22(20)15-7-3-2-4-8-15)23(29)18-9-5-6-10-19(18)24(27)30/h2-14,22,31-32H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis				Bioorg Med Chem Lett 14: 1339-42 (2004) Article DOI: 10.1016/j.bmcl.2003.11.081 BindingDB Entry DOI: 10.7270/Q2PR7VDS
					More data for this Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial (Homo sapiens (Human))	BDBM50140723 (5-(4-methoxyphenyl)-3-phenyl-(3R,3aS,6aR)-spiro[pe...) Show SMILES COc1ccc(cc1)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1 Show InChI InChI=1S/C27H19NO6/c1-33-17-13-11-16(12-14-17)28-25(31)20-21(26(28)32)27(34-22(20)15-7-3-2-4-8-15)23(29)18-9-5-6-10-19(18)24(27)30/h2-14,22,31-32H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human phenylalanyl-tRNA synthetase was determined				Bioorg Med Chem Lett 14: 1339-42 (2004) Article DOI: 10.1016/j.bmcl.2003.11.081 BindingDB Entry DOI: 10.7270/Q2PR7VDS
					More data for this Ligand-Target Pair