BDBM50140729 13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-(1S,2R,9S,12S,13R,14R)-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3(8),4,6-triene-13-carboxamide::CHEMBL284654
SMILES: O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
InChI Key: InChIKey=SJCQIKMJLOJSKF-JMKVLMKQSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenylalanyl-tRNA synthetase mitochondrial (Homo sapiens (Human)) | BDBM50140729 (13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase | Bioorg Med Chem Lett 14: 1343-6 (2004) Article DOI: 10.1016/j.bmcl.2003.11.082 BindingDB Entry DOI: 10.7270/Q2K073Q6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanyl-tRNA synthetase mitochondrial (Homo sapiens (Human)) | BDBM50140729 (13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase | Bioorg Med Chem Lett 14: 1343-6 (2004) Article DOI: 10.1016/j.bmcl.2003.11.082 BindingDB Entry DOI: 10.7270/Q2K073Q6 | |||||||||||
More data for this Ligand-Target Pair |