BDBM50140730 4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phenylspiro[tetrahydrofuran-2,2'-(2',3'-dihydro-1'H-indene)]-3-carboxylic acid::CHEMBL29865

SMILES: OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=DGONOJGFUJFZOV-ACRUOGEOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140730   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phenylalanyl-tRNA synthetase mitochondrial (Homo sapiens (Human))	BDBM50140730 (4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phen...) Show SMILES OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C26H17Cl2NO6/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(33)34)26(35-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,19-21H,(H,29,32)(H,33,34)/t19-,20-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase				Bioorg Med Chem Lett 14: 1343-6 (2004) Article DOI: 10.1016/j.bmcl.2003.11.082 BindingDB Entry DOI: 10.7270/Q2K073Q6
					More data for this Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial (Homo sapiens (Human))	BDBM50140730 (4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phen...) Show SMILES OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C26H17Cl2NO6/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(33)34)26(35-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,19-21H,(H,29,32)(H,33,34)/t19-,20-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase				Bioorg Med Chem Lett 14: 1343-6 (2004) Article DOI: 10.1016/j.bmcl.2003.11.082 BindingDB Entry DOI: 10.7270/Q2K073Q6
					More data for this Ligand-Target Pair