BDBM50142192 3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL6665
SMILES: Oc1ccc(c(O)c1)-c1coc2cc(O)cc(O)c2c1=O
InChI Key: InChIKey=GSSOWCUOWLMMRJ-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Lysozyme C (Rattus norvegicus) | BDBM50142192 (3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaohsiung Medical University Curated by ChEMBL | Assay Description Inhibitory effect of compound on the release of lysozyme in rat neutrophils stimulated with fMLP/CB | Bioorg Med Chem Lett 14: 1011-4 (2004) Article DOI: 10.1016/j.bmcl.2003.11.074 BindingDB Entry DOI: 10.7270/Q2C829VG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estradiol 17-beta-dehydrogenase 2 (Homo sapiens (Human)) | BDBM50142192 (3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Basel Curated by ChEMBL | Assay Description Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin... | J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estradiol 17-beta-dehydrogenase 1 (Homo sapiens (Human)) | BDBM50142192 (3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Basel Curated by ChEMBL | Assay Description Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting... | J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-glucuronidase (Rattus norvegicus) | BDBM50142192 (3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaohsiung Medical University Curated by ChEMBL | Assay Description Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB | Bioorg Med Chem Lett 14: 1011-4 (2004) Article DOI: 10.1016/j.bmcl.2003.11.074 BindingDB Entry DOI: 10.7270/Q2C829VG | |||||||||||
More data for this Ligand-Target Pair |