BDBM50142525 CHEMBL47524::N-(4,5-Dihydro-thiazol-2-yl)-3,4,5-trihydroxy-benzamide

SMILES: Oc1cc(cc(O)c1O)C(=O)NC1=NCCS1

InChI Key: InChIKey=NTBBUWBAFBYPGL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50142525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50142525 (CHEMBL47524 | N-(4,5-Dihydro-thiazol-2-yl)-3,4,5-t...) Show SMILES Oc1cc(cc(O)c1O)C(=O)NC1=NCCS1 |t:13| Show InChI InChI=1S/C10H10N2O4S/c13-6-3-5(4-7(14)8(6)15)9(16)12-10-11-1-2-17-10/h3-4,13-15H,1-2H2,(H,11,12,16)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed form				Bioorg Med Chem Lett 14: 1669-72 (2004) Article DOI: 10.1016/j.bmcl.2004.01.060 BindingDB Entry DOI: 10.7270/Q2GX4B0X
					More data for this Ligand-Target Pair