BDBM50145101 CHEMBL3763674
SMILES: Fc1ccc(cc1)C1C(Nc2cccc3c2c1n[nH]c3=O)c1ccc(CN2CCC2)cc1
InChI Key: InChIKey=UMTZOWPWZLHANK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50145101 (CHEMBL3763674) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
BioMarin Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assay | J Med Chem 59: 335-57 (2016) BindingDB Entry DOI: 10.7270/Q2K35WJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50145101 (CHEMBL3763674) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
BioMarin Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis | J Med Chem 59: 335-57 (2016) BindingDB Entry DOI: 10.7270/Q2K35WJR | |||||||||||
More data for this Ligand-Target Pair |