BDBM50145655 CHEMBL3763681

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cnnc(c1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F

InChI Key: InChIKey=TUPRAOVBKWMGGF-AVKWCDSFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145655 (CHEMBL3763681) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cnnc(c1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F |r| Show InChI InChI=1S/C25H26ClF3N6O3/c1-15-4-7-35(33-15)20-10-16(26)2-3-18(20)22(25(27,28)29)38-17-11-21(32-31-13-17)34-8-5-24(6-9-34)12-19(23(36)37)30-14-24/h2-4,7,10-11,13,19,22,30H,5-6,8-9,12,14H2,1H3,(H,36,37)/t19?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair