BDBM50145656 CHEMBL3764128

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cncc(n1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F

InChI Key: InChIKey=CZMRKRQXIVGFQM-LMNIDFBRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145656   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145656 (CHEMBL3764128) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cncc(n1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F |r| Show InChI InChI=1S/C25H26ClF3N6O3/c1-15-4-7-35(33-15)19-10-16(26)2-3-17(19)22(25(27,28)29)38-21-13-30-12-20(32-21)34-8-5-24(6-9-34)11-18(23(36)37)31-14-24/h2-4,7,10,12-13,18,22,31H,5-6,8-9,11,14H2,1H3,(H,36,37)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair