BDBM50145660 CHEMBL3763485

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)[C@@H]1CCN(C[C@H](N)C(O)=O)C1)C(F)(F)F

InChI Key: InChIKey=BLWIZPVHQXWZSA-JOTOCRJQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145660   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145660 (CHEMBL3763485) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)[C@@H]1CCN(C[C@H](N)C(O)=O)C1)C(F)(F)F |r| Show InChI InChI=1S/C23H25ClF3N7O3/c1-12-4-7-34(32-12)18-8-14(24)2-3-15(18)20(23(25,26)27)37-19-9-17(30-22(29)31-19)13-5-6-33(10-13)11-16(28)21(35)36/h2-4,7-9,13,16,20H,5-6,10-11,28H2,1H3,(H,35,36)(H2,29,30,31)/t13-,16+,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair