BDBM50145662 CHEMBL3765662

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC(CCC(O)=O)CC1)C(F)(F)F

InChI Key: InChIKey=MCASPTNTLDPYIW-JOCHJYFZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145662 (CHEMBL3765662) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC(CCC(O)=O)CC1)C(F)(F)F |r| Show InChI InChI=1S/C24H26ClF3N6O3/c1-14-6-11-34(32-14)18-12-16(25)3-4-17(18)22(24(26,27)28)37-20-13-19(30-23(29)31-20)33-9-7-15(8-10-33)2-5-21(35)36/h3-4,6,11-13,15,22H,2,5,7-10H2,1H3,(H,35,36)(H2,29,30,31)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair