BDBM50145669 CHEMBL3763846

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)C#CC[C@H](N)C(O)=O)C(F)(F)F

InChI Key: InChIKey=APCHLCRLRXCXHK-MAUKXSAKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145669 (CHEMBL3763846) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)C#CC[C@H](N)C(O)=O)C(F)(F)F |r| Show InChI InChI=1S/C21H18ClF3N6O3/c1-11-7-8-31(30-11)16-9-12(22)5-6-14(16)18(21(23,24)25)34-17-10-13(28-20(27)29-17)3-2-4-15(26)19(32)33/h5-10,15,18H,4,26H2,1H3,(H,32,33)(H2,27,28,29)/t15-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair