BDBM50145671 CHEMBL3764568

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CC2(C1)CNC(C2)C(O)=O)C(F)(F)F

InChI Key: InChIKey=HUBVBMJVJWLCRM-XCWJXAQQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145671   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145671 (CHEMBL3764568) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CC2(C1)CNC(C2)C(O)=O)C(F)(F)F |r| Show InChI InChI=1S/C23H23ClF3N7O3/c1-12-4-5-34(32-12)16-6-13(24)2-3-14(16)19(23(25,26)27)37-18-7-17(30-21(28)31-18)33-10-22(11-33)8-15(20(35)36)29-9-22/h2-7,15,19,29H,8-11H2,1H3,(H,35,36)(H2,28,30,31)/t15?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair