BDBM50145673 CHEMBL3765147

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(NC2CCCCC2)n1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F

InChI Key: InChIKey=DPLKYMPQVFRMOZ-IQHZPMLTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM50145673 (CHEMBL3765147) Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(NC2CCCCC2)n1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F |r| Show InChI InChI=1S/C31H37ClF3N7O3/c1-19-9-12-42(40-19)24-15-20(32)7-8-22(24)27(31(33,34)35)45-26-16-25(38-29(39-26)37-21-5-3-2-4-6-21)41-13-10-30(11-14-41)17-23(28(43)44)36-18-30/h7-9,12,15-16,21,23,27,36H,2-6,10-11,13-14,17-18H2,1H3,(H,43,44)(H,37,38,39)/t23?,27-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Karos Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of TPH1 (unknown origin)				Bioorg Med Chem Lett 26: 1124-9 (2016) BindingDB Entry DOI: 10.7270/Q2WD42DJ
					More data for this Ligand-Target Pair