BDBM50146304 3'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-((S)-3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cycloheptene-10-carbonyl)-phenyl]-amide::CHEMBL432043
SMILES: COc1cccc(c1)-c1ccccc1C(=O)Nc1ccc(C(=O)N2C[C@H]3COCCN3Cc3ccccc23)c(Cl)c1
InChI Key: InChIKey=OYXSDPJBBYGUKY-VWLOTQADSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM50146304 (3'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor | Bioorg Med Chem Lett 14: 2747-52 (2004) Article DOI: 10.1016/j.bmcl.2004.03.083 BindingDB Entry DOI: 10.7270/Q2QN679W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM50146304 (3'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor | Bioorg Med Chem Lett 14: 2747-52 (2004) Article DOI: 10.1016/j.bmcl.2004.03.083 BindingDB Entry DOI: 10.7270/Q2QN679W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM50146304 (3'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor | Bioorg Med Chem Lett 14: 2747-52 (2004) Article DOI: 10.1016/j.bmcl.2004.03.083 BindingDB Entry DOI: 10.7270/Q2QN679W | |||||||||||
More data for this Ligand-Target Pair |