BDBM50147344 (2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-{4-[3-(3,4,5-trimethoxy-phenyl)-acryloylamino]-phenyl}-butyramide::CHEMBL110672

SMILES: COc1cc(\C=C\C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc(OC)c1OC

InChI Key: InChIKey=DZCLXCJXXAQLFM-PEDYAIFJSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50147344   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50147344 ((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-{4-[3-(3,...) Show SMILES COc1cc(\C=C\C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc(OC)c1OC Show InChI InChI=1S/C28H37N3O6/c1-35-23-16-19(17-24(36-2)27(23)37-3)9-14-25(32)30-20-10-12-21(13-11-20)31-28(34)26(33)22(29)15-18-7-5-4-6-8-18/h9-14,16-18,22,26,33H,4-8,15,29H2,1-3H3,(H,30,32)(H,31,34)/b14-9+/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description In vitro inhibition of human recombinant Methionine aminopeptidase 2.				Bioorg Med Chem Lett 14: 3181-4 (2004) Article DOI: 10.1016/j.bmcl.2004.04.004 BindingDB Entry DOI: 10.7270/Q2J38S1M
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50147344 ((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-{4-[3-(3,...) Show SMILES COc1cc(\C=C\C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc(OC)c1OC Show InChI InChI=1S/C28H37N3O6/c1-35-23-16-19(17-24(36-2)27(23)37-3)9-14-25(32)30-20-10-12-21(13-11-20)31-28(34)26(33)22(29)15-18-7-5-4-6-8-18/h9-14,16-18,22,26,33H,4-8,15,29H2,1-3H3,(H,30,32)(H,31,34)/b14-9+/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
Northwest University Curated by ChEMBL					Assay Description Inhibition of human MetAP2				Eur J Med Chem 173: 213-227 (2019) Article DOI: 10.1016/j.ejmech.2019.04.009
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50147344 ((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-{4-[3-(3,...) Show SMILES COc1cc(\C=C\C(=O)Nc2ccc(NC(=O)[C@@H](O)[C@H](N)CC3CCCCC3)cc2)cc(OC)c1OC Show InChI InChI=1S/C28H37N3O6/c1-35-23-16-19(17-24(36-2)27(23)37-3)9-14-25(32)30-20-10-12-21(13-11-20)31-28(34)26(33)22(29)15-18-7-5-4-6-8-18/h9-14,16-18,22,26,33H,4-8,15,29H2,1-3H3,(H,30,32)(H,31,34)/b14-9+/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description In vitro inhibition of human recombinant Methionine aminopeptidase 2.				Bioorg Med Chem Lett 14: 3181-4 (2004) Article DOI: 10.1016/j.bmcl.2004.04.004 BindingDB Entry DOI: 10.7270/Q2J38S1M
					More data for this Ligand-Target Pair