BDBM50148621 CHEMBL3770029

SMILES: COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO

InChI Key: InChIKey=HAPWXFMEXBTXSE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50148621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50148621 (CHEMBL3770029) Show SMILES COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO Show InChI InChI=1S/C15H12N2O4/c1-20-12-5-4-9-6-11(3-2-10(9)7-12)15-16-13(8-21-15)14(18)17-19/h2-8,19H,1H3,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-University Freiburg Curated by ChEMBL					Assay Description Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis				J Med Chem 59: 1545-55 (2016) BindingDB Entry DOI: 10.7270/Q2X350BD
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50148621 (CHEMBL3770029) Show SMILES COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO Show InChI InChI=1S/C15H12N2O4/c1-20-12-5-4-9-6-11(3-2-10(9)7-12)15-16-13(8-21-15)14(18)17-19/h2-8,19H,1H3,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.91E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-University Freiburg Curated by ChEMBL					Assay Description Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis				J Med Chem 59: 1545-55 (2016) BindingDB Entry DOI: 10.7270/Q2X350BD
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50148621 (CHEMBL3770029) Show SMILES COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO Show InChI InChI=1S/C15H12N2O4/c1-20-12-5-4-9-6-11(3-2-10(9)7-12)15-16-13(8-21-15)14(18)17-19/h2-8,19H,1H3,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-University Freiburg Curated by ChEMBL					Assay Description Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis				J Med Chem 59: 1545-55 (2016) BindingDB Entry DOI: 10.7270/Q2X350BD
					More data for this Ligand-Target Pair