BDBM50148740 8-(2-Benzyloxy-ethyl)-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]octane::CHEMBL325826

SMILES: Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCOCc1ccccc1)c1ccc(F)cc1

InChI Key: InChIKey=PVLOMLBAVRLZPH-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50148740   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50148740 (8-(2-Benzyloxy-ethyl)-3-[bis-(4-fluoro-phenyl)-met...) Show SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCOCc1ccccc1)c1ccc(F)cc1 |THB:8:9:16:12.13| Show InChI InChI=1S/C29H31F2NO2/c30-24-10-6-22(7-11-24)29(23-8-12-25(31)13-9-23)34-28-18-26-14-15-27(19-28)32(26)16-17-33-20-21-4-2-1-3-5-21/h1-13,26-29H,14-20H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Ability of compound to inhibit dopamine uptake of receptor was determined				Bioorg Med Chem Lett 15: 2149-57 (2005) Article DOI: 10.1016/j.bmcl.2005.02.012 BindingDB Entry DOI: 10.7270/Q2RR20G2
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50148740 (8-(2-Benzyloxy-ethyl)-3-[bis-(4-fluoro-phenyl)-met...) Show SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCOCc1ccccc1)c1ccc(F)cc1 |THB:8:9:16:12.13| Show InChI InChI=1S/C29H31F2NO2/c30-24-10-6-22(7-11-24)29(23-8-12-25(31)13-9-23)34-28-18-26-14-15-27(19-28)32(26)16-17-33-20-21-4-2-1-3-5-21/h1-13,26-29H,14-20H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	48.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL					Assay Description Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.				J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50148740 (8-(2-Benzyloxy-ethyl)-3-[bis-(4-fluoro-phenyl)-met...) Show SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCOCc1ccccc1)c1ccc(F)cc1 |THB:8:9:16:12.13| Show InChI InChI=1S/C29H31F2NO2/c30-24-10-6-22(7-11-24)29(23-8-12-25(31)13-9-23)34-28-18-26-14-15-27(19-28)32(26)16-17-33-20-21-4-2-1-3-5-21/h1-13,26-29H,14-20H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL					Assay Description Binding affinity at muscarinic M1 receptor in rat brain by [3H]pirenzepine displacement.				J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50148740 (8-(2-Benzyloxy-ethyl)-3-[bis-(4-fluoro-phenyl)-met...) Show SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCOCc1ccccc1)c1ccc(F)cc1 |THB:8:9:16:12.13| Show InChI InChI=1S/C29H31F2NO2/c30-24-10-6-22(7-11-24)29(23-8-12-25(31)13-9-23)34-28-18-26-14-15-27(19-28)32(26)16-17-33-20-21-4-2-1-3-5-21/h1-13,26-29H,14-20H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL					Assay Description Binding affinity at serotonin transporter in rat brain by [3H]-citalopram displacement.				J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4
					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50148740 (8-(2-Benzyloxy-ethyl)-3-[bis-(4-fluoro-phenyl)-met...) Show SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCOCc1ccccc1)c1ccc(F)cc1 |THB:8:9:16:12.13| Show InChI InChI=1S/C29H31F2NO2/c30-24-10-6-22(7-11-24)29(23-8-12-25(31)13-9-23)34-28-18-26-14-15-27(19-28)32(26)16-17-33-20-21-4-2-1-3-5-21/h1-13,26-29H,14-20H2	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat brain				J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4
					More data for this Ligand-Target Pair