BDBM50149266 3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL117637

SMILES: COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)N)c1=O

InChI Key: InChIKey=UUYVCIJKZWTODH-LBPRGKRZSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50149266   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50149266 (3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)N)c1=O |wD:26.29,(24.66,-3.65,;23.32,-4.42,;23.32,-5.96,;24.67,-6.73,;24.66,-8.27,;23.32,-9.04,;21.99,-8.26,;21.99,-6.73,;20.66,-5.95,;20.66,-9.01,;20.66,-10.55,;21.99,-11.32,;19.32,-11.34,;19.32,-12.88,;20.65,-13.65,;20.65,-15.19,;19.3,-15.96,;21.98,-15.96,;23.32,-15.19,;23.32,-13.63,;21.98,-12.86,;23.06,-11.77,;17.99,-10.55,;16.64,-11.32,;17.99,-9.01,;16.66,-8.24,;15.31,-9.01,;15.31,-10.55,;13.98,-8.24,;19.33,-8.24,;19.33,-6.7,)| Show InChI InChI=1S/C22H22F3N3O3/c1-12(26)10-28-21(29)19(14-6-4-9-18(31-3)20(14)25)13(2)27(22(28)30)11-15-16(23)7-5-8-17(15)24/h4-9,12H,10-11,26H2,1-3H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50149266 (3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)N)c1=O |wD:26.29,(24.66,-3.65,;23.32,-4.42,;23.32,-5.96,;24.67,-6.73,;24.66,-8.27,;23.32,-9.04,;21.99,-8.26,;21.99,-6.73,;20.66,-5.95,;20.66,-9.01,;20.66,-10.55,;21.99,-11.32,;19.32,-11.34,;19.32,-12.88,;20.65,-13.65,;20.65,-15.19,;19.3,-15.96,;21.98,-15.96,;23.32,-15.19,;23.32,-13.63,;21.98,-12.86,;23.06,-11.77,;17.99,-10.55,;16.64,-11.32,;17.99,-9.01,;16.66,-8.24,;15.31,-9.01,;15.31,-10.55,;13.98,-8.24,;19.33,-8.24,;19.33,-6.7,)| Show InChI InChI=1S/C22H22F3N3O3/c1-12(26)10-28-21(29)19(14-6-4-9-18(31-3)20(14)25)13(2)27(22(28)30)11-15-16(23)7-5-8-17(15)24/h4-9,12H,10-11,26H2,1-3H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair