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BDBM50149669 CHEMBL183148::[2,5-Dimethyl-3-(3-methyl-5-nitro-pyridin-2-yl)-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine

SMILES: CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)[N+]([O-])=O

InChI Key: InChIKey=GYFFFGHMKGSACD-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50149669   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149669
PNG
(CHEMBL183148 | [2,5-Dimethyl-3-(3-methyl-5-nitro-p...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)[N+]([O-])=O |(7.55,-.03,;6.02,.19,;5.44,1.62,;3.89,1.8,;3.31,3.23,;4.24,4.46,;3.66,5.89,;2.96,.58,;3.54,-.84,;2.61,-2.06,;3.19,-3.47,;1.08,-1.86,;.5,-.43,;-.95,.09,;-.91,1.62,;-2.12,2.55,;.57,2.06,;1.44,.77,;-2.36,-.59,;-2.36,-2.15,;-3.69,-2.91,;-5.03,-2.15,;-5.03,-.59,;-3.69,.19,;-3.69,1.72,;-6.36,-2.91,;-7.72,-2.15,;-6.36,-4.47,)|
Show InChI InChI=1S/C20H26N6O2/c1-6-8-24(9-7-2)17-11-14(4)22-20-18(15(5)23-25(17)20)19-13(3)10-16(12-21-19)26(27)28/h10-12H,6-9H2,1-5H3
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PubMed
9.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149669
PNG
(CHEMBL183148 | [2,5-Dimethyl-3-(3-methyl-5-nitro-p...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)[N+]([O-])=O |(7.55,-.03,;6.02,.19,;5.44,1.62,;3.89,1.8,;3.31,3.23,;4.24,4.46,;3.66,5.89,;2.96,.58,;3.54,-.84,;2.61,-2.06,;3.19,-3.47,;1.08,-1.86,;.5,-.43,;-.95,.09,;-.91,1.62,;-2.12,2.55,;.57,2.06,;1.44,.77,;-2.36,-.59,;-2.36,-2.15,;-3.69,-2.91,;-5.03,-2.15,;-5.03,-.59,;-3.69,.19,;-3.69,1.72,;-6.36,-2.91,;-7.72,-2.15,;-6.36,-4.47,)|
Show InChI InChI=1S/C20H26N6O2/c1-6-8-24(9-7-2)17-11-14(4)22-20-18(15(5)23-25(17)20)19-13(3)10-16(12-21-19)26(27)28/h10-12H,6-9H2,1-5H3
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9.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149669
PNG
(CHEMBL183148 | [2,5-Dimethyl-3-(3-methyl-5-nitro-p...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)[N+]([O-])=O |(7.55,-.03,;6.02,.19,;5.44,1.62,;3.89,1.8,;3.31,3.23,;4.24,4.46,;3.66,5.89,;2.96,.58,;3.54,-.84,;2.61,-2.06,;3.19,-3.47,;1.08,-1.86,;.5,-.43,;-.95,.09,;-.91,1.62,;-2.12,2.55,;.57,2.06,;1.44,.77,;-2.36,-.59,;-2.36,-2.15,;-3.69,-2.91,;-5.03,-2.15,;-5.03,-.59,;-3.69,.19,;-3.69,1.72,;-6.36,-2.91,;-7.72,-2.15,;-6.36,-4.47,)|
Show InChI InChI=1S/C20H26N6O2/c1-6-8-24(9-7-2)17-11-14(4)22-20-18(15(5)23-25(17)20)19-13(3)10-16(12-21-19)26(27)28/h10-12H,6-9H2,1-5H3
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n/an/a 180n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149669
PNG
(CHEMBL183148 | [2,5-Dimethyl-3-(3-methyl-5-nitro-p...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)[N+]([O-])=O |(7.55,-.03,;6.02,.19,;5.44,1.62,;3.89,1.8,;3.31,3.23,;4.24,4.46,;3.66,5.89,;2.96,.58,;3.54,-.84,;2.61,-2.06,;3.19,-3.47,;1.08,-1.86,;.5,-.43,;-.95,.09,;-.91,1.62,;-2.12,2.55,;.57,2.06,;1.44,.77,;-2.36,-.59,;-2.36,-2.15,;-3.69,-2.91,;-5.03,-2.15,;-5.03,-.59,;-3.69,.19,;-3.69,1.72,;-6.36,-2.91,;-7.72,-2.15,;-6.36,-4.47,)|
Show InChI InChI=1S/C20H26N6O2/c1-6-8-24(9-7-2)17-11-14(4)22-20-18(15(5)23-25(17)20)19-13(3)10-16(12-21-19)26(27)28/h10-12H,6-9H2,1-5H3
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n/an/a 180n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CRF-stimulated cAMP production in cells expressing CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair