US11026923, Example 142 1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)methyl]-5-(2-propoxy-3- pyridyl)pyrazolo[4,3-b]pyridin-7-amine

SMILES: CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC

InChI Key: InChIKey=SJMDRHYXKHAMKH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM501512 (1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)me...) Show SMILES CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C24H31N7O/c1-6-11-32-24-19(9-8-10-25-24)20-12-21(26-13-18-14-30(5)15-27-18)23-22(28-20)17(4)29-31(23)16(3)7-2/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM501512 (1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)me...) Show SMILES CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C24H31N7O/c1-6-11-32-24-19(9-8-10-25-24)20-12-21(26-13-18-14-30(5)15-27-18)23-22(28-20)17(4)29-31(23)16(3)7-2/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM501512 (1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)me...) Show SMILES CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C24H31N7O/c1-6-11-32-24-19(9-8-10-25-24)20-12-21(26-13-18-14-30(5)15-27-18)23-22(28-20)17(4)29-31(23)16(3)7-2/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair