BDBM50152804 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[2-(4-fluoro-phenyl)-ethylamino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide::CHEMBL184526

SMILES: Fc1ccc(CCNCc2ccccc2N2CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)cc1

InChI Key: InChIKey=PSXOZKLCEKKWIU-VSJLXWSYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50152804   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50152804 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Fc1ccc(CCNCc2ccccc2N2CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)cc1 Show InChI InChI=1S/C38H41ClFN5O2/c39-32-13-9-28(10-14-32)23-35(43-37(46)34-24-29-5-1-2-6-30(29)26-42-34)38(47)45-21-19-44(20-22-45)36-8-4-3-7-31(36)25-41-18-17-27-11-15-33(40)16-12-27/h1-16,34-35,41-42H,17-26H2,(H,43,46)/t34-,35-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	81	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptor				Bioorg Med Chem Lett 14: 4417-23 (2004) Article DOI: 10.1016/j.bmcl.2004.06.059 BindingDB Entry DOI: 10.7270/Q2251HPH
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50152804 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Fc1ccc(CCNCc2ccccc2N2CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)cc1 Show InChI InChI=1S/C38H41ClFN5O2/c39-32-13-9-28(10-14-32)23-35(43-37(46)34-24-29-5-1-2-6-30(29)26-42-34)38(47)45-21-19-44(20-22-45)36-8-4-3-7-31(36)25-41-18-17-27-11-15-33(40)16-12-27/h1-16,34-35,41-42H,17-26H2,(H,43,46)/t34-,35-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	487	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptor				Bioorg Med Chem Lett 14: 4417-23 (2004) Article DOI: 10.1016/j.bmcl.2004.06.059 BindingDB Entry DOI: 10.7270/Q2251HPH
					More data for this Ligand-Target Pair