BDBM50154616 2-Fluoro-4b,9,10-triaza-benzo[b]fluorene-5,11-dione::4-aza-8-fluorotryptanthrin::CHEMBL187652::US10669273, Compound CY-1-2

SMILES: Fc1ccc-2c(c1)C(=O)c1nc3ncccc3c(=O)n-21

InChI Key: InChIKey=AKHMUNBSKUODAD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase Pfmrk (Plasmodium falciparum)	BDBM50154616 (2-Fluoro-4b,9,10-triaza-benzo[b]fluorene-5,11-dion...) Show SMILES Fc1ccc-2c(c1)C(=O)c1nc3ncccc3c(=O)n-21 Show InChI InChI=1S/C14H6FN3O2/c15-7-3-4-10-9(6-7)11(19)13-17-12-8(2-1-5-16-12)14(20)18(10)13/h1-6H	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Walter Reed Army Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum cyclin-dependent kinase				J Med Chem 47: 5418-26 (2004) Article DOI: 10.1021/jm040108f BindingDB Entry DOI: 10.7270/Q2BZ66TW
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50154616 (2-Fluoro-4b,9,10-triaza-benzo[b]fluorene-5,11-dion...) Show SMILES Fc1ccc-2c(c1)C(=O)c1nc3ncccc3c(=O)n-21 Show InChI InChI=1S/C14H6FN3O2/c15-7-3-4-10-9(6-7)11(19)13-17-12-8(2-1-5-16-12)14(20)18(10)13/h1-6H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University US Patent					Assay Description Experimental method: IDO-1 can oxidatively cleave the indole ring of tryptophan to form N-formylkynurenine. Referring to the method in the literature...				US Patent US10669273 (2020)
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50154616 (2-Fluoro-4b,9,10-triaza-benzo[b]fluorene-5,11-dion...) Show SMILES Fc1ccc-2c(c1)C(=O)c1nc3ncccc3c(=O)n-21 Show InChI InChI=1S/C14H6FN3O2/c15-7-3-4-10-9(6-7)11(19)13-17-12-8(2-1-5-16-12)14(20)18(10)13/h1-6H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University US Patent					Assay Description Experimental method: IDO-1 can oxidatively cleave the indole ring of tryptophan to form N-formylkynurenine. Referring to the method in the literature...				US Patent US10669273 (2020)
					More data for this Ligand-Target Pair