BDBM50157328 7-(1-Quinolin-4-yl-piperidin-4-ylmethoxy)-3,4-dihydro-1H-isoquinoline-2-carboxamidine; dihydrochloride::CHEMBL535367

SMILES: NC(=N)N1CCc2ccc(OCC3CCN(CC3)c3ccnc4ccccc34)cc2C1

InChI Key: InChIKey=WQVKYLFBJMWDHZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50157328 (7-(1-Quinolin-4-yl-piperidin-4-ylmethoxy)-3,4-dihy...) Show SMILES NC(=N)N1CCc2ccc(OCC3CCN(CC3)c3ccnc4ccccc34)cc2C1 Show InChI InChI=1S/C25H29N5O/c26-25(27)30-14-10-19-5-6-21(15-20(19)16-30)31-17-18-8-12-29(13-9-18)24-7-11-28-23-4-2-1-3-22(23)24/h1-7,11,15,18H,8-10,12-14,16-17H2,(H3,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Central Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory concentration against human Coagulation factor X				J Med Chem 48: 3586-604 (2005) Article DOI: 10.1021/jm058160e BindingDB Entry DOI: 10.7270/Q2CR5V36
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50157328 (7-(1-Quinolin-4-yl-piperidin-4-ylmethoxy)-3,4-dihy...) Show SMILES NC(=N)N1CCc2ccc(OCC3CCN(CC3)c3ccnc4ccccc34)cc2C1 Show InChI InChI=1S/C25H29N5O/c26-25(27)30-14-10-19-5-6-21(15-20(19)16-30)31-17-18-8-12-29(13-9-18)24-7-11-28-23-4-2-1-3-22(23)24/h1-7,11,15,18H,8-10,12-14,16-17H2,(H3,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Central Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory concentration against human Coagulation factor II (thrombin)				J Med Chem 48: 3586-604 (2005) Article DOI: 10.1021/jm058160e BindingDB Entry DOI: 10.7270/Q2CR5V36
					More data for this Ligand-Target Pair