BDBM50158564 1-(5-Chloro-2-hydroxy-phenyl)-3-(3-trifluoromethyl-phenyl)-urea::1-(5-chloro-2-hydroxyphenyl)-3-(3-trifluoromethylphenyl)urea::CHEMBL33891
SMILES: Oc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)C(F)(F)F
InChI Key: InChIKey=KRHJDJMOIKRPNN-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GRIK1 (Homo sapiens (Human)) | BDBM50158564 (1-(5-Chloro-2-hydroxy-phenyl)-3-(3-trifluoromethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Antagonist activity at human homomeric GluR5 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLIPR assay | J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT | |||||||||||
More data for this Ligand-Target Pair |